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Mechanisms of PARP Inhibitor Resistance

Mark J O'Connor1, Josep V Forment2

  • 1Oncology R&D, AstraZeneca, Discovery Centre, Cambridge Biomedical Campus, 1 Francis Crick Avenue, Cambridge, CB2 0AA, UK. mark.j.oconnor@astrazeneca.com.

Cancer Treatment and Research
|November 17, 2023
PubMed

Keywords:
ATRHomologous recombination repair (HRR)Hypomorphic mutantsMicrohomology-mediated end joiningPARP inhibitor (PARPi) resistancePolymerase thetaReplication stressReversion mutationsWEE1

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