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Published on: November 9, 2019
Brønsted Acid-Mediated Multicomponent One-Pot Approach to Direct Construction of 4-Aryl-hydrocoumarin Derivatives
Pragya Sharma1, Sanjay Singh1, Chinmoy Kumar Hazra1
1Department of Chemistry, Indian Institute of Technology Delhi, New Delhi 110016, India.
Abstract:
The facile and efficient synthesis of a unique class of 4-aryl-hydrocoumarins having enormous applications in medicinal chemistry and natural products is presented. We have for the first time developed a Brønsted acid-catalyzed, multicomponent, one-pot approach for producing various 4-aryl-coumarin derivatives. The feedstock availability of these precursors allowed access to a wide range of 2-chromanone derivatives in good to excellent yields under mild conditions. The practicality of this protocol was justified by the synthesis of bioactive compounds, late-stage functionalization of natural products, and gram-scale synthesis.
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