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Updated: Jul 10, 2025
08:14
Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
13.0K
Extended platelet-rich fibrin.
Richard J Miron1,2, Michael A Pikos3, Nathan E Estrin1
1Advanced PRF Education, Jupiter, Florida, USA.
Periodontology 2000
|November 21, 2023
Summary
A novel heating process transforms platelet-rich fibrin (PRF) into extended-PRF (e-PRF), a regenerative biomaterial with a 4-6 month resorption period. This enhanced e-PRF shows promise as a collagen membrane alternative in dentistry and orthopedics.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Periodontology and Implant Dentistry
Background:
- Platelet-rich fibrin (PRF) is a regenerative biomaterial with a short resorption period of 2-3 weeks.
- There is a clinical need for longer-lasting regenerative materials in various medical and dental applications.
Purpose of the Study:
- To review the scientific literature on extended-PRF (e-PRF) technology, a novel heated PRF variant.
- To summarize the preclinical and clinical findings on e-PRF's properties and applications.
- To explore the potential of e-PRF as a substitute for collagen membranes and as a regenerative filler.
Main Methods:
- Systematic literature review using keywords: Bio-Heat, albumin gel, albumin-PRF, Alb-PRF, extended-PRF, e-PRF, activated plasma albumin gel, APAG.
- Databases searched: MEDLINE, EMBASE, PubMed.
- Inclusion of preclinical studies (ISO 10993) and clinical case studies.
Main Results:
- A 10-minute heating process transforms liquid albumin into a gel, extending resorption to at least 4 months (ISO 10993 preclinical data).
- Clinical studies demonstrate e-PRF membrane use as a substitute for collagen membranes in guided bone regeneration (GBR), sinus lifts, and recession coverage.
- Alb-PRF shows potential as an injectable filler for joint injections, osteoarthritis, and facial aesthetics due to its extended duration.
Conclusions:
- The novel Alb-PRF/e-PRF technology significantly improves stability and degradation properties compared to traditional PRF.
- e-PRF shows widespread potential as a cost-effective, natural alternative to collagen membranes in various dental and orthopedic procedures.
- Further research into Alb-PRF/e-PRF is encouraged for its application as a regenerative filler and biomaterial.
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