Dynamic Susceptibility Contrast Perfusion, Part 2: Deployment With and Without Contrast Leakage Present

Area of Science:

• Radiology
• Medical Imaging
• Neuroimaging

Background:

• Dynamic susceptibility contrast (DSC) Magnetic Resonance (MR) imaging is a key technique for perfusion analysis.
• Understanding DSC MR acquisition concepts is crucial for accurate interpretation.

Purpose of the Study:

• To describe the fundamental principles of DSC MR imaging acquisition.
• To explain the requirements for pulse sequences used in DSC MR imaging.

Main Methods:

• Utilizes MR imaging pulse sequences sensitive to magnetic susceptibility changes.
• Employs T2*-weighted sequences capable of detecting contrast concentration variations.

Main Results:

• Successful registration of contrast concentration changes relies on susceptibility-sensitive pulse sequences.
• Image acquisition speed is critical, requiring at least 1-2 second intervals per tissue slice.

Conclusions:

• T2*-weighted sequences are suitable for DSC MR imaging if acquisition is sufficiently rapid.
• Proper DSC MR acquisition is essential for reliable perfusion analysis.