Related Experiment Video
Updated: Jul 8, 2025

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Published on: February 18, 2022
Chronic heart failure with reduced EF: A decade of major pharmacological innovations
1Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Background And Objectives:
Because of its severity, prevalence, and medical economic importance, heart failure is a chronic disease that is the subject of intense medical research. The aim of this article was to review the therapeutic innovations of the last decade that have been incorporated into the latest international recommendations for the treatment of heart failure.
Method:
Review of literature and current guidelines.
Conclusion:
The results of the clinical trials reviewed here represent major advances that will have a significant impact on quality of life, survival, rehospitalisation and, for certain treatments, a beneficial joint effect on commonly associated comorbidities such as diabetes and chronic renal failure.
Related Concept Videos
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Pathophysiology of Heart Failure
Heart Failure Drugs: Diuretics
Heart Failure Drugs: β-Blockers
Heart Failure Drugs: Inotropic Agents
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...

