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Updated: Jul 8, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Synthesis of Fluorinated Amines: A Personal Account
Yi Yang1, Alexis Taponard1, Julien C Vantourout1
1Univ Lyon, CNRS, Université Claude Bernard Lyon 1, ICBMS, UMR 5246, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne, France.
Abstract:
This Account highlights the recent contributions made by our laboratory in the development of novel strategies to synthesize fluorinated amines. These strategies allow the practitioner to efficiently access carbamoyl fluorides, thiocarbamoyl fluorides as well as trifluoromethylamines using CO2 or CS2 as benign C1 sources. In addition, a novel N(SCF3)CF3 moiety was synthesized. Noteworthy, we demonstrated that this reagent could also be used in radical- or electrophilic-based trifluoromethylthiolation reactions.
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