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Related Experiment Video

Updated: Jul 8, 2025

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat
12:41

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

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Where do we stand on fMRI in awake mice?

Francesca Mandino1, Stella Vujic2, Joanes Grandjean3,4

  • 1Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, United States.

Cerebral Cortex (New York, N.Y. : 1991)
|December 15, 2023
PubMed
Summary

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Bayesian generative modeling reveals a multi-modal hierarchical architecture in the mouse functional connectome.

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Awake mouse functional MRI (fMRI) is advancing neuroscience by removing anesthesia effects. Standardization and stress characterization are crucial for progress in this imaging technique.

Area of Science:

  • Neuroscience
  • Medical Imaging

Background:

  • Anesthesia confounds neuroimaging results and limits studying awake brain states.
  • Awake animal imaging is critical for inter-species translation and comprehensive brain research.

Approach:

  • Systematic review analyzing 30 articles on awake mouse blood oxygen level dependent functional magnetic resonance imaging (fMRI) from 2011-2022.
  • Included an overview of awake rat fMRI studies for comparative context.

Key Points:

  • Head-posts are favorable for awake mouse fMRI.
  • 10-14 days of acclimation training may suffice under specific conditions.
  • The impact of stress in awake fMRI studies is not well-characterized.

Conclusions:

  • More standardization is needed to accelerate progress in awake mouse fMRI.
Keywords:
anesthesiaawakefMRIfunctional magnetic resonance imagingrodentunanesthetized

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  • Recommendations are provided to benefit diverse neuroscience applications.
  • Awake fMRI offers whole-brain coverage ideal for cross-species comparisons.