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Labeling DNA Probes

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

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Updated: Jul 8, 2025

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes

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Engineering cyanine cyclizations for new fluorogenic probes

Quintashia D Wilson¹, Ellen M Sletten²

¹Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA.

Nature Chemistry

|December 18, 2023

Summary

No abstract available in PubMed .

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