Related Experiment Video
Updated: Jul 5, 2025
Deep Vascular Imaging in the Eye with Flow-Enhanced Ultrasound
Published on: October 4, 2021
Microvascular flow ultrasound imaging for retinoblastoma
Aparna Ramasubramanian1, Monique Riemann2, Alex Brown3
1Medical College of Wisconsin, Milwaukee, Wisconsin.
Purpose:
To present the results of a pilot study of microvascular flow imaging (MFI) in characterizing tumor vasculature of retinoblastoma.
Methods:
The medical records of consecutive patients with retinoblastoma presenting at our institution between July 2019 and June 2022 that were imaged using MFI were reviewed retroactively. Each patient underwent diagnostic evaluation according to standard of care by examination under anesthesia with fluorescein angiography and ocular ultrasound imaging, including color Doppler and MFI.
Results:
Thirteen eyes of 10 patients with retinoblastoma were included. MFI showed a prominent feeder vessel in 8 eyes, basket vasculature in 6 eyes and tumor bed vascularity in 10 eyes. MFI showed a more extensive vascular branching pattern that was not visible on color Doppler and fluorescein angiography in all eyes.
Conclusions:
MFI of retinoblastoma patients could add information about tumor vascularity not detectable by color Doppler or fluorescein angiography. Further study is needed to determine whether this information could be used to predict prognosis for ocular salvage and tumor response to treatment.
