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NeuroBus - Architecture for an Ultra-Flexible Neural Interface.

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    NeuroBus is a novel neural implant system architecture. Its ultra-flexible design with tiny, direct-digitizing neural recorder ASICs offers high biocompatibility and adaptability for brain interfacing.

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    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Materials Science

    Background:

    • Developing advanced neural implants is crucial for understanding brain function and treating neurological disorders.
    • Existing neural interfaces often face challenges with biocompatibility, wiring complexity, and adaptability to brain curvature.

    Purpose of the Study:

    • To present the system architecture of NeuroBus, a novel implant concept for neural recording.
    • To detail the integrated components, fabrication processes, and performance of the NeuroBus system.

    Main Methods:

    • Designed a bus-like architecture connecting tiny, direct-digitizing neural recorder Application-Specific Integrated Circuits (ASICs) on an ultra-flexible polyimide substrate.
    • Developed and characterized the ASICs and the polyimide-based electrocorticography (ECoG) brain interface.
    • Validated the system's performance using a rodent animal model.

    Main Results:

    • Demonstrated a low bending stiffness implant that conforms to brain curvature, enhancing structural biocompatibility.
    • Achieved short connections between electrodes and recording front-ends with reduced wiring complexity and high customizability.
    • Validated the joint capability of the direct-digitizing neural recorder front-end and thin-film electrode array in vivo.

    Conclusions:

    • The NeuroBus architecture offers a promising solution for high-density, biocompatible neural recording.
    • The system's design facilitates adaptability and customizability for advanced brain-computer interfaces.
    • This technology has the potential to significantly advance neural recording capabilities for research and clinical applications.