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Updated: Jul 5, 2025
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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
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Microparticles and multi-unit systems for advanced drug delivery.
Nikolett Kállai-Szabó1, Dóra Farkas1, Miléna Lengyel1
1Department of Pharmaceutics, Semmelweis University, Hőgyes Str. 7, H-1092 Budapest, Hungary.
Summary
Multiparticulate drug delivery systems offer enhanced safety, efficacy, and patient convenience through tailored microparticle formulations. Innovations like 3D printing are expanding possibilities for advanced drug delivery systems.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Technologies
Background:
- Multiparticulate systems, utilizing microparticles, offer significant advantages in pharmaceutical formulations.
- These systems improve drug safety, efficacy, pharmacokinetics, and patient-centricity, including ease of swallowing and dosing flexibility.
Approach:
- This review explores advancements in multiparticulate system technologies, from established methods to innovative solutions.
- It covers the diversity of multiparticulate systems, various administration routes, and the role of excipients.
- The applicability of novel technologies like 3D printing for creating tailored subunits is also discussed.
Key Points:
- Microparticles enable improved drug release profiles, mucoadhesion, and floating capabilities for optimized delivery.
- Current market formulations can achieve long-term drug release (3-6 months).
- The versatility in particle size (from 1 µm) and formulation technologies supports future drug development.
Conclusions:
- Multiparticulate systems provide a robust platform for developing advanced pharmaceutical dosage forms.
- Continued innovation in formulation and manufacturing technologies promises expanded applications and improved patient outcomes.
Keywords:
Drug releaseMicrocapsulesMicroparticulateMicrospheresMinitabletsMultiparticulate systemsPelletsMore Related Videos
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