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Artificial Endothelial Layer Implantation After Multiple Failed Keratoplasties
Jasmien Rens1,2, Iva Krolo1,3,4, Carina Koppen1,2
1Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium.
Cornea
|January 18, 2024
Summary
A novel noncellular corneal endothelial substitute offers a promising alternative for patients with multiple failed corneal transplants. This artificial endothelial layer demonstrated sustained attachment and corneal deswelling over 12 months.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Regenerative Medicine
Background:
- Corneal endothelial dysfunction can result from multiple failed grafts, including penetrating keratoplasty (PK) and lamellar endothelial keratoplasty.
- Pseudophakic bullous keratopathy presents a significant challenge in patients with a history of graft rejection.
