EFFECTIVENESS OF THE APPLICATION OF THE DEVELOPED BIOPOLYMER FIBROUS MATRIX WITH CENOBONE® BIOGEL FOR THE...

The aim of the research was to study the framework ability of the fibrous non-woven PCL matrices we've created during the restoration of bone tissue.There were performed some spectroscopic, histological and immunohistochemical, radiological and clinical analyses of the effectiveness of microfibrous non-woven PCL polycaprolactone matrices developed by us, in the work. The obtained results of morphological studies of bone tissue in the experiment of the implantation of a fibrous matrix indicated an increase in reparative osteogenesis in the form of an increase in osteoid areas up to 34.38% (p<0.05) at an early period. The analysis of clinical data showed the effectiveness of the frame developed by us, which was confirmed by the absence of pronounced compaction of bone tissue in group III, in contrast to group II, where, on the contrary, the use of granulate based on hydroxyapatite and tricalcium phosphate has led to a significant increase in density indices of 974.53+19.74 HU p<0.05, which did not exceed 36.8% of indices of the group III 615.17+24.53 HU p<0.05.The matrix material developed by us is not only a means of delivering some other substances and materials into the damaged area, but also serves as a kind of framework for the restoration of bone tissue.