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[Detection of enterotoxigenic enterobacteria with adhesion antigens in acute intestinal diseases]
Insights
Enterobacteria producing enterotoxins and adhesion antigens are found in over 56% of infants with acute intestinal disease. These specific enterobacteria were absent in healthy children, suggesting a role in pediatric intestinal illness.
Area of Science:
- Microbiology
- Pediatric Gastroenterology
- Veterinary Medicine
Context:
- Acute intestinal diseases in children under 1 year often have an unknown etiology.
- Enterobacteria are common inhabitants of the gastrointestinal tract.
- Diarrhea is a significant health concern in both human infants and young domestic animals.
Purpose:
- To investigate the presence and characteristics of enterobacteria in children with acute intestinal diseases of unknown etiology.
- To compare the prevalence of specific enterobacteria in sick children versus healthy children.
- To examine the occurrence of similar enterobacteria in cases of diarrhea in piglets and calves.
Summary:
- A significant proportion (56.8 +/- 4.3%) of infants under 1 year with acute intestinal disease of unknown origin harbored enterobacteria capable of synthesizing both enterotoxins and adhesion antigens.
- These specific enterobacteria were not isolated from healthy children.
- Enterobacteria with both toxigenicity and adhesion antigen production capabilities were frequently found in piglets (50.6 +/- 4.8%) and calves (42.9 +/- 4.8%) suffering from diarrhea.
Impact:
- This study identifies a potential microbial marker for acute intestinal diseases in infants.
- Findings suggest a common pathogenic mechanism involving enterobacteria in pediatric and animal intestinal infections.
- Highlights the need for further research into the role of these enterobacteria in disease pathogenesis and potential therapeutic targets.
Abstract:
As revealed in this study, 56.8 +/- 4.3% of children under 1 year, suffering from acute intestinal diseases of unknown (i.e. not determined by common bacteriological methods) etiology, show the presence of enterobacteria capable of the combined synthesis of enterotoxins and adhesion antigens. No such cultures are isolated from healthy children. In cases of diarrhea of domestic animals (piglets and calves), frequent isolation of enterobacteria characterized by both, toxigenicity and capacity for producing adhesion antigens (50.6 +/- 4.8% and 42.9 +/- 4.8% respectively), is noted.