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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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The Bone Matrix01:18

The Bone Matrix

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Updated: Jul 4, 2025

Biological Compatibility Profile on Biomaterials for Bone Regeneration
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Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

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Bioactive elements manipulate bone regeneration.

Long Bai1,2,3, Peiran Song1,3, Jiacan Su1,2,3

  • 1Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, China.

Biomaterials Translational
|January 29, 2024
PubMed
Summary
This summary is machine-generated.

Bioactive elements like zinc, magnesium, and silicon offer a stable, safe alternative to traditional growth factors for bone regeneration. These elements, integrated into biomaterials, enhance bone healing through controlled release mechanisms.

Keywords:
bioactive elementsbiomaterialsbone organoidbone regenerationcontrollable release

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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Research

Background:

  • Bone tissue possesses natural regenerative capabilities, but disease and injury impair bone formation and resorption.
  • Current bone regeneration strategies often use external agents like growth factors, facing limitations in safety and transient efficacy.
  • The need for advanced, stable, and safe methods for bone regeneration is critical.

Purpose of the Study:

  • To review the mechanistic roles and therapeutic efficacy of bioactive elements in bone regeneration.
  • To establish bioactive elements as a clinically viable strategy for advanced bone regeneration.
  • To highlight the advantages of bioactive elements over traditional growth factors.

Main Methods:

  • Literature review focusing on the integration of bioactive elements (zinc, magnesium, silicon) into biomaterials.
  • Analysis of the mechanisms by which these elements influence bone formation and resorption.
  • Evaluation of the therapeutic benefits, stability, and safety profiles of bioactive elements.

Main Results:

  • Bioactive elements (Zn, Mg, Si) demonstrate therapeutic benefits for bone regeneration.
  • These elements offer superior stability and reduced biotic risks compared to conventional agents.
  • Incorporation into biomaterials allows for on-demand release, enhancing regenerative potential.

Conclusions:

  • Bioactive elements represent a robust and clinically viable strategy for bone regeneration.
  • The use of bioactive elements in biomaterials overcomes limitations associated with traditional growth factors.
  • Further research into bioactive elements will advance bone tissue engineering and clinical applications.