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Related Concept Videos

Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

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Standard Solutions01:14

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Related Experiment Video

Updated: Jul 12, 2026

Automated Multiplex Immunofluorescence Panel for Immuno-oncology Studies on Formalin-fixed Carcinoma Tissue Specimens
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The Ozaki Procedure: Standardized Protocol Adoption of a Complex Innovative Procedure.

Viral Patel1, Shinya Unai1, Ryan Moore1

  • 1Department of Thoracic and Cardiovascular Surgery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Structural Heart : the Journal of the Heart Team
|January 29, 2024
PubMed
Summary

The Ozaki procedure for aortic valve replacement is reproducible with a standardized approach, showing a short learning curve and excellent patient outcomes, including improved quality of life.

Keywords:
Aortic regurgitationAortic stenosisAortic valveBicuspid aortic valveCardiac surgeryCongenital heart diseaseValvular heart disease

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Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Biomaterials Science

Background:

  • The Ozaki procedure offers an alternative for aortic valve replacement using autologous pericardium.
  • This technique presents complexity, necessitating standardized methods to ensure reproducibility and minimize the learning curve.

Purpose of the Study:

  • To present a standardized approach for the Ozaki procedure to reduce the learning curve and confirm its reproducibility.
  • To evaluate the perioperative outcomes, intermediate-term valve hemodynamics, quality of life, and survival rates following the Ozaki procedure.

Main Methods:

  • A standardized Ozaki procedure was performed on 46 patients between May 2015 and February 2021.
  • Data collected included operative times, perioperative outcomes, valve hemodynamics, reintervention rates, quality of life (MacNew questionnaire), and mortality.

Main Results:

  • Operative times decreased over the initial 20 cases, indicating a learning curve.
  • No major perioperative morbidity or mortality was observed; 2-year survival was 96%.
  • Patients demonstrated stable valve hemodynamics, improved left ventricular function, and enhanced quality of life compared to norms.

Conclusions:

  • A standardized approach facilitates a reproducible Ozaki procedure with a short learning curve.
  • The Ozaki procedure demonstrates excellent intermediate-term hemodynamic performance and improves patient quality of life.