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Sjögren's Disease and Oral Health: A Genetic Instrumental Variable Analysis.
S L Reckelkamm1,2, Z Alayash1, B Holtfreter3
1Institute of Health Services Research in Dentistry, University of Münster, Münster, Germany.
Journal of Dental Research
|January 29, 2024
Summary
Sjögren's disease (SjD) significantly increases the risk of dental caries and periodontitis. This study used genetic data to confirm SjD's detrimental impact on oral health, supporting its role as a risk factor.
Area of Science:
- Oral health research
- Autoimmune disease epidemiology
- Genetic epidemiology
Background:
- Sjögren's disease (SjD) is linked to increased dental caries risk.
- SjD's association with periodontitis is less established due to observational study biases.
- Instrumental variable analysis can mitigate bias in etiological research.
Purpose of the Study:
- To investigate the causal effect of Sjögren's disease (SjD) on the risk of dental caries and periodontitis.
- To address limitations of observational studies using a genetic instrumental variable approach.
Main Methods:
- Utilized 57 genetic variants associated with SjD from a large genome-wide association study.
- Employed an instrumental variable (IVW) analysis to assess SjD's impact on caries and periodontitis.
- Conducted sensitivity analyses to ensure the robustness of the findings.
Main Results:
- Sjögren's disease (SjD) demonstrated a significant adverse effect on dental caries (β = 0.039, P = 6.3e-16).
- SjD was also associated with an increased risk of periodontitis (OR = 1.033, P = 2.3e-05).
- Sensitivity analyses corroborated the primary findings.
Conclusions:
- Sjögren's disease (SjD) has a detrimental effect on dental caries.
- The study provides evidence suggesting SjD promotes periodontitis.
- The genetic instrumental variable approach confirms SjD as a risk factor for both conditions.
Keywords:
Mendelian randomization analysisdental cariesgenetic epidemiologyimmunityperiodontitissalivaMore Related Videos
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