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Related Experiment Video

Updated: Jul 4, 2025

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

SUBCLINICAL OPTIC NEURITIS.

Tomislav Vidović¹, Branimir Cerovski¹, Smiljka Popović-Suić¹

¹Department of Ophthalmology, Zagreb University Hospital Center, School of Medicine, University of Zagreb, Zagreb, Croatia.

Acta Clinica Croatica

|February 2, 2024

Summary

Multiple sclerosis (MS) patients without optic neuritis often have vision problems. Functional vision tests reveal significant visual field defects and reduced contrast sensitivity in these individuals.

Keywords:

Multiple sclerosis Optic neuritis Vision tests

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Area of Science:

Ophthalmology
Neurology

Background:

Acute optic neuritis is a common ocular symptom in multiple sclerosis (MS).
Subclinical optic neuritis in MS patients is slow, bilateral, and often unnoticed.
Assessing vision impairment in MS patients without a history of acute optic neuritis is crucial.

Purpose of the Study:

To evaluate vision impairment in multiple sclerosis patients without a history of acute optic neuritis.
To utilize functional vision tests for detecting subclinical visual deficits.

Main Methods:

Included 35 MS patients (aged 18-50) with normal visual acuity and no subjective vision impairment.
Employed Octopus 101 perimetry (N1 program) for visual field testing.
Utilized Pelli Robson charts for contrast sensitivity and Ishihara plates for color vision testing.

Main Results:

Visual field defects were detected in 28 patients (80%).
Common defects included peripheral retinal sensitivity depression and nerve fiber bundle defects.
Reduced contrast sensitivity was found in 86% of patients.

Conclusions:

Multiple sclerosis patients without apparent optic neuritis experience significant vision function impairment.
Octopus perimetry and Pelli Robson contrast sensitivity testing are effective in detecting these subclinical deficits.