Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Deep learning-based effusion-synovitis volume measured on MRI is associated with osteoarthritis progression: A longitudinal analysis of data from the osteoarthritis initiative.

Osteoarthritis and cartilage open·2026

Same author

Correction: ISSLS Prize in Clinical Science 2026: Data-driven classification of lumbar spine degeneration trajectories in chronic low back pain.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026

Same author

Standardized Knee Meniscus MRI Reporting: An Interdisciplinary Delphi Consensus.

Radiology·2026

Same author

CT-based 3D bone shape modes are associated with clinically meaningful functional improvement after total knee arthroplasty.

Osteoarthritis and cartilage open·2026

Same author

Deep learning-based quantification of knee effusion-synovitis volume on MRI - Technique development and validation.

Osteoarthritis and cartilage·2026

Same author

Quantitative Disk and Metabolic Bone PET-MRI for Understanding Disk-Endplate Crosstalk in Degeneration of the Lumbar Spine.

JOR spine·2026

Search research articles

Related Experiment Video

Updated: Jul 4, 2025

An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants

An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants

Published on: November 3, 2019

Biomarkers of Cartilage Composition.

Maximilian T Löffler^1,2,3, Zehra Akkaya^1,4, Rupsa Bhattacharjee¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.

Seminars in Musculoskeletal Radiology

|February 8, 2024

Summary

Compositional magnetic resonance imaging (MRI) techniques, including T2 and T1rho mapping, are crucial for detecting early osteoarthritis (OA) damage. These advanced MRI methods visualize cartilage composition, aiding in early diagnosis and prevention of structural damage.

More Related Videos

Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants

Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants

Published on: May 14, 2020

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Related Experiment Videos

Last Updated: Jul 4, 2025

An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants

An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants

Published on: November 3, 2019

Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants

Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants

Published on: May 14, 2020

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Area of Science:

Biomedical Imaging
Osteoarthritis Research
Biomaterials Science

Background:

Osteoarthritis (OA) involves progressive cartilage degeneration.
Cartilage has limited self-repair capabilities due to its avascular nature.
Early detection of structural and compositional changes is vital for OA management.

Purpose of the Study:

To review compositional magnetic resonance imaging (MRI) techniques for osteoarthritis.
To highlight the importance of assessing cartilage composition and ultrastructure.
To discuss the clinical feasibility and comparability of advanced MRI biomarkers.

Main Methods:

Compositional MRI techniques visualize noncalcified tissues like cartilage.
Spin-spin relaxation time (T2) and spin-lattice relaxation time constant in rotating frame (T1rho) mapping are key biomarkers.
Other techniques include dGEMRIC, gagCEST, sodium imaging, and diffusion-weighted MRI.

Main Results:

Compositional MRI provides insights into cartilage integrity beyond morphological imaging.
Standardization efforts (e.g., QIBA) aim to enhance clinical utility and comparability of MRI biomarkers.
Various advanced techniques offer complementary information on cartilage health.

Conclusions:

Compositional MRI is essential for understanding OA pathogenesis and progression.
Advanced MRI techniques enable detection of premorphological damage, crucial for prevention.
Further development and standardization of these techniques will improve clinical OA assessment.