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Aloe Vera-based Biomaterial Ink For 3d Bioprinting Of Wound Dressing Constructs.

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Aloe Vera-based Biomaterial Ink For 3d Bioprinting Of Wound Dressing Constructs.

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Aloe vera-based biomaterial ink for 3D bioprinting of wound dressing constructs.

M Camila Ceballos-Santa¹, Alfonso Sierra², Iker Martinez Zalbidea²

¹Department of Industrial and Systems Engineering, Rochester Institute of Technology, Rochester, New York, USA.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials

|February 13, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This study developed an Aloe vera-based biomaterial ink for advanced wound healing. This innovative ink promotes tissue regeneration and combats infection, offering a promising solution for effective wound dressing bioprinting.

Keywords:

Aloe vera Extrusion-based bioprinting Hydrogels Skin tissue regeneration Wound dressing

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Area of Science:

Biomaterials Science
Regenerative Medicine
Tissue Engineering

Background:

Standardized printable biomaterials with adequate properties are scarce for clinical wound healing applications.
Aloe vera possesses inherent biocompatible, biodegradable, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory properties beneficial for wound repair.
Existing wound healing strategies often require supplementary agents to manage infection and promote regeneration.

Purpose of the Study:

To develop a multifunctional biomaterial ink utilizing Aloe vera for wound healing constructs.
To address the limitations of current printable biomaterials in terms of biocompatibility and physicochemical properties.
To create a standardized, effective material for bioprinting advanced wound dressings.

Main Methods:

Aloe vera was incorporated into a biomaterial ink.
Ionic crosslinking was employed to enhance rheological and mechanical properties.
Bioprinting of constructs was performed, followed by characterization of microstructure, mechanical strength, and biological response (stem cell viability).

Main Results:

The Aloe vera biomaterial ink exhibited enhanced viscoelastic behavior, superior compressive modulus, and fine filament extrusion capabilities.
Bioprinted constructs showed desirable resolution, mechanical strength, and a porous microstructure similar to the native extracellular matrix.
Live/dead assays confirmed no detrimental impact on stem cell viability when exposed to the biomaterial ink.

Conclusions:

The developed Aloe vera-based biomaterial ink is suitable for bioprinting wound dressings.
The ink leverages Aloe vera's inherent properties to promote cellular proliferation and enhance wound healing.
This biomaterial offers a promising, standardized resource for advanced wound care applications.