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Updated: Jul 2, 2025

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Performing In Vivo and Ex Vivo Electrical Impedance Myography in Rodents
Published on: June 8, 2022
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A Bioimpedance Spectroscopy Interface for EIM Based on IF-Sampling and Pseudo 2-Path SC Bandpass ∆Σ ADC
IEEE Transactions on Biomedical Circuits and Systems
|February 26, 2024
Summary
This study introduces a low-noise bioimpedance spectroscopy interface for electrical impedance myography. The system accurately detects muscle contractions, showing potential for wearable EIM devices.
Area of Science:
- Biomedical Engineering
- Electrical Engineering
- Signal Processing
Background:
- Electrical Impedance Myography (EIM) requires accurate bioimpedance measurements.
- Existing interfaces face challenges in noise, power efficiency, and data throughput for detecting muscle contractions.
Purpose of the Study:
- To present a novel low-noise bioimpedance spectroscopy interface for EIM.
- To achieve high accuracy and efficiency in bioimpedance readings across a wide frequency range.
- To demonstrate the interface's capability for detecting muscle activity.
Main Methods:
- Utilized a direct-digital-synthesis (DDS) sinusoidal signal generator for accurate bioimpedance readings.
- Employed a quadrature low-intermediate frequency (IF) readout with low-gain IAs and bandpass ∆Σ ADCs.
- Implemented the interface in a 180 nm CMOS process.
Main Results:
- Achieved 0.7 mΩ/Hz sensitivity at 15.625 kHz and 105.8 dB SNR within a 4 Hz bandwidth.
- Demonstrated a figure-of-merit of 146.5 dB, indicating excellent performance.
- Successfully recorded EIM data during bicep brachii muscle contractions.
Conclusions:
- The proposed bioimpedance spectroscopy interface offers a low-noise, efficient solution for EIM.
- The system's performance is suitable for detecting muscle contractions in real-time.
- This technology holds significant potential for developing advanced wearable EIM systems.
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