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Updated: Jul 2, 2025

Use of Dual Optical Tweezers and Microfluidics for Single-Molecule Studies

Use of Dual Optical Tweezers and Microfluidics for Single-Molecule Studies

Published on: November 18, 2022

Localized Plasmonic Heating for Single-Molecule DNA Rupture Measurements in Optical Tweezers.

Prerna Kabtiyal¹, Ariel Robbins², Elizabeth Jergens²

¹Department of Physics, The Ohio State University, Columbus, Ohio 43210, United States.

|February 28, 2024

Summary

This summary is machine-generated.

Researchers demonstrate localized heating at the single-molecule level using gold nanoparticles (AuNPs). This technique enables precise control over nanomachines and biomolecular studies for improved understanding of thermodynamic and kinetic processes.

Keywords:

DNA force spectroscopy optical tweezers plasmonic heating single-molecule

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Area of Science:

Nanotechnology
Biophysics
Physical Chemistry

Background:

Studies on biological function and nanomachine actuation often use ensemble measurements.
Localized heating probes are needed to resolve single-molecule responses.

Purpose of the Study:

To demonstrate wavelength-selective, localized heating at the single-molecule level.
To enable studies of single-molecule thermodynamic properties and nanomachine actuation.

Main Methods:

Utilizing the surface plasmon resonance of 15 nm gold nanoparticles (AuNPs).
Integrating AuNP heating with force-spectroscopy measurements.
Demonstrating wavelength selectivity and temperature dependence of base-pair disruption.

Main Results:

Experimental demonstration of localized heating at the single-molecule level.
Compatibility with force-spectroscopy for studying DNA origami nanomachines and biomolecular complexes.
Established wavelength selectivity and temperature dependence for base-pair rupture.

Conclusions:

The developed approach provides a flexible method for fundamental studies of local temperature gradients.
Enables rapid and multiplexed nanomachine actuation.
Offers new possibilities for investigating single-molecule thermodynamics and kinetics in biological systems.