Ponatinib: A comprehensive drug profile

Area of Science:

• Medicinal Chemistry
• Pharmacology
• Analytical Chemistry

Background:

• Ponatinib is a tyrosine kinase inhibitor crucial for treating resistant Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) and chronic myeloid leukemia (CML).
• Understanding its synthesis, properties, and analytical methods is vital for effective therapeutic application.

Approach:

• This chapter reviews existing literature on ponatinib synthesis and physicochemical properties.
• It details structural characterization using techniques like NMR, MS, and XRD.
• A comprehensive survey of non-compendial analytical methods (spectroscopic, chromatographic, immunoassay) and pharmacokinetic/pharmacodynamic studies is presented.

Key Points:

• Synthesis and physicochemical properties of ponatinib are elucidated.
• Various analytical techniques for ponatinib characterization are discussed, including spectroscopic and chromatographic methods.
• Pharmacological and biochemical aspects, including pharmacokinetics and pharmacodynamics, are surveyed.

Conclusions:

• This review consolidates knowledge on ponatinib's synthesis, characterization, and analysis.
• It highlights the need for robust analytical methods for this important anti-cancer drug.
• The findings support further research into ponatinib's therapeutic potential and application.