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A Case of Doxycycline-Induced Pancreatitis
Jeremiah Kakes1, William E Cayley2,3, Justin Sporleder4
1Wisconsin North Central GME Consortium (WiNC), Prevea Family Medicine Residency, Eau Claire, Wisconsin, kakesjeremiah@gmail.com.
Acute pancreatitis, a common U.S. hospitalization cause, can be induced by doxycycline. This case highlights the likely link between doxycycline use and acute pancreatitis, emphasizing the need for further research.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Acute pancreatitis is a significant cause of hospital admissions in the United States.
- The etiology of acute pancreatitis is multifactorial, requiring thorough investigation for each case.
Observation:
- A 64-year-old male presented with acute epigastric pain, elevated lipase, and CT findings consistent with moderate peripancreatic inflammation.
- The patient had no history of alcohol abuse or gallbladder disease but had recently commenced doxycycline therapy.
- Hospitalization included supportive care for pancreatitis and antibiotics for aspiration pneumonia.
Findings:
- The patient's symptoms resolved with supportive care, suggesting a drug-induced etiology.
- Doxycycline-induced pancreatitis has a reported onset of 3 to 17 days after initiation.
- The temporal relationship and absence of other causes strongly implicated doxycycline.
Implications:
- This case underscores the importance of considering drug-induced pancreatitis, specifically with doxycycline.
- Further research is warranted to elucidate the pathophysiology and incidence of doxycycline-induced pancreatitis.
Related Concept Videos
01:30Acute Pancreatitis II: Clinical Manifestations and Management
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:27Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:29Chronic Pancreatitis II: Collaborative Care
Assessment: