Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and vice versa

Area of Science:

• Materials Science
• Biochemistry
• Nanotechnology

Background:

• Self-assembled monolayers (SAMs) are ordered molecular assemblies with broad applications.
• Peptide building blocks are increasingly utilized for their complex structures and biological relevance.
• Existing research showcases peptide-displaying SAMs for various functions.

Purpose of the Study:

• To review advancements in peptide-based SAMs.
• To discuss peptide selection, design, and functionalization strategies.
• To present fabrication methods and characterization techniques for peptide SAMs.

Main Methods:

• Literature review of peptide-based SAMs research.
• Analysis of peptide selection, design, and functionalization.
• Discussion of advanced fabrication and characterization techniques.

Main Results:

• Peptide SAMs enable selective cell adhesion, migration, and differentiation.
• Applications include biomolecular binding, biosensing, molecular electronics, and antimicrobial surfaces.
• Dynamic peptide presentation methods enhance spatiotemporal control.
• Characterization techniques validate structural and functional properties.

Conclusions:

• Peptide-based SAMs are versatile platforms for studying biological processes.
• They offer convergent approaches for high-throughput screening of therapeutics and technologies.
• Advanced design and fabrication enable complex, functional peptide SAMs.