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Updated: Jun 30, 2025

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Guide to Lung-Protective Ventilation in Cardiac Patients
Aniket S Rali1, Lena Tran1, Aditi Balakrishna2
1Division of Cardiovascular Diseases, Vanderbilt University Medical Center, Nashville, TN.
Positive pressure ventilation (PPV) is crucial for acute respiratory insufficiency in cardiac intensive care. Understanding lung-protective ventilation (LPV) and its effects on heart function is vital for cardiologists.
Area of Science:
- Cardiology
- Pulmonology
- Intensive Care Medicine
Background:
- Increasing incidence of acute respiratory insufficiency in cardiovascular intensive care units (CICUs).
- Positive pressure ventilation (PPV) is the primary treatment modality for these patients.
- PPV significantly impacts cardiovascular performance due to alterations in intrathoracic pressure.
Purpose of the Study:
- To highlight the importance of understanding lung-protective ventilation (LPV) in CICU patients.
- To elucidate the cardiopulmonary interactions associated with PPV.
- To emphasize the benefits of LPV for cardiologists managing critically ill cardiac patients.
Main Methods:
- Review of current literature on PPV and LPV in cardiovascular critical care.
- Analysis of the physiological effects of altered intrathoracic pressure on cardiac function.
- Discussion of ventilator-induced lung injury (VILI) and its prevention.
Main Results:
- PPV alters right and left ventricular function through changes in intrathoracic pressure.
- LPV strategies aim to minimize ventilator-induced lung injury (VILI).
- Effective LPV can mitigate adverse cardiovascular effects in critically ill patients.
Conclusions:
- Cardiologists must understand the cardiopulmonary interactions of PPV.
- Implementing LPV is crucial for reducing lung injury and optimizing cardiovascular stability.
- Knowledge of LPV benefits cardiologists in managing respiratory and cardiac dysfunction concurrently.
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