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Updated: Jun 29, 2025

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Peptidomics Strategies to Evaluate Cancer Diagnosis, Prognosis, and Treatment
Daniella Figueiredo1, Rodrigo G B Cruz1, Ana Gabriela Costa Normando1
1Laboratório Nacional de Biociências, LNBio, Centro Nacional de Pesquisa em Energia e Materiais, CNPEM, Campinas, SP, Brazil.
Abstract:
Peptides have potential bioactive functions, and the peptidomics landscape has been broadly investigated for various diseases, including cancer. In this chapter, we reviewed the past four years of literature available and selected 16 peer-reviewed publications exploring peptidomics in diagnosis, prognosis, and treatment in cancer research. We highlighted their main aims, mass spectrometry-based peptidomics, multi-omics, data-driven and in silico strategies, functional assays, and clinical applications. Moreover, we underscored several levels of difficulties in translating the peptidomics findings to clinical practice, aiming to learn with the accumulated knowledge and guide upcoming studies. Finally, this review reinforces the peptidomics robustness in discovering potential candidates for monitoring the several stages of cancer disease and therapeutic treatment, leveraging the management of cancer patients in the future.
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