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Updated: Jun 29, 2025

Generation of Monoclonal Antibodies Against Natural Products
Published on: April 6, 2019
[Understanding hypersensitivity reactions to monoclonal antibodies]
Viola Cattaneo1, Mhedi Belkoniene1, Raphaël Porret1
1Service d'immunologie et allergies, Département de médecine interne, Centre hospitalier universitaire vaudois, 1011 Lausanne.
Abstract:
Biologic drugs are complex molecules synthesized by a living organism. Their use is increasingly prevalent across all medical specialties, exposing a growing number of patients to potential adverse reactions. In this review, we discuss the new classification of hypersensitivity reactions, along with the specific characteristics of monoclonal antibodies. We also address the available diagnostic tools and discuss the management of those reactions, including for patients requiring the continuation of these biologic drugs.
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