Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

122
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
122
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

96
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
96
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

469
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
469
Language and Cognition01:27

Language and Cognition

343
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
343
Mitochondria01:37

Mitochondria

12.4K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
12.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-Model Machine Learning for Survival Predictions for Castration-Resistant Prostate Cancer.

Cancers·2026
Same author

Health care utilization in veterans with Alzheimer disease.

The American journal of managed care·2026
Same author

Ethics and Data in Precision Nutrition: A Roadmap for Responsible Innovation.

The Journal of nutrition·2026
Same author

A Randomized Multicenter Study Comparing Low-Viscosity with Comparator 0.3% Hyaluronic Acid for the Treatment of Dry Eye Disease.

Ophthalmology and therapy·2026
Same author

Food insecurity and physical functioning in Boston area Puerto Rican older adults.

Public health nutrition·2026
Same author

pH-sensitive poly(vinyl alcohol)/quercetin/curcumin nanofiber membrane for food freshness monitoring.

Food chemistry·2026

Related Experiment Video

Updated: Jun 29, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.5K

Metabolites and Cognitive Decline in a Puerto Rican Cohort.

Scott Gordon1, Jong Soo Lee2,3, Tammy M Scott4

  • 1Department of Computer Science, University of Massachusetts Lowell, Lowell, MA, USA.

Journal of Alzheimer'S Disease : JAD
|April 5, 2024
PubMed
Summary

Certain fatty acids and tyrosine metabolites are linked to cognitive decline in Puerto Ricans. These findings may help identify early biomarkers for cognitive health in this population.

Keywords:
Alzheimer’s diseaseLatinosPuerto ricancognitive declinemetabolomics

More Related Videos

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

13.7K
Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.3K

Related Experiment Videos

Last Updated: Jun 29, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.5K
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

13.7K
Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.3K

Area of Science:

  • Metabolomics
  • Neuroscience
  • Population Health

Background:

  • Limited research exists on plasma metabolites and cognitive decline in Latino populations, particularly Puerto Ricans.
  • Previous studies identified plasma metabolites associated with cognitive decline and Alzheimer's disease.

Purpose of the Study:

  • To investigate the association between plasma metabolites and cognitive trajectory in Puerto Ricans.
  • To contribute to metabolomics research for improving Latino health outcomes.

Main Methods:

  • Assessed 621 plasma metabolites using untargeted metabolomic profiling in 736 Boston Puerto Rican Health Study participants.
  • Utilized linear mixed models with metabolite*time interaction to analyze cognitive changes over approximately 12 years.
  • Controlled for relevant covariates in the statistical analysis.

Main Results:

  • Identified inverse associations between medium-chain fatty acids (caproic acid) and dicarboxylic acids (azelaic, sebacic acid) with global cognition.
  • Observed that N-formylphenylalanine, a tyrosine metabolite, was associated with an improved cognitive trajectory.
  • These findings suggest specific metabolic pathways influencing cognitive health.

Conclusions:

  • Metabolites identified in this study align with existing literature on cognitive decline.
  • Highlight the potential roles of medium-chain fatty acid and tyrosine metabolism in cognitive trajectories.
  • Emphasize the importance of studying diverse populations in metabolomics research.