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Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
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Updated: Jun 28, 2025

A Straightforward Method for Glucosinolate Extraction and Analysis with High-pressure Liquid Chromatography HPLC
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A Straightforward Method for Glucosinolate Extraction and Analysis with High-pressure Liquid Chromatography HPLC

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Do Brassica Vegetables Affect Thyroid Function?-A Comprehensive Systematic Review.

Agnieszka Galanty1, Marta Grudzińska2,3, Wojciech Paździora1,3

  • 1Department of Pharmacognosy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.

International Journal of Molecular Sciences
|April 13, 2024
PubMed
Summary

Consuming Brassica vegetables, rich in glucosinolates (GLSs) and isothiocyanates (ITCs), does not negatively impact thyroid function in humans. This systematic review found no adverse effects, especially with adequate iodine intake.

Keywords:
Hashimoto diseasebrassicadietgoiterhypothyroidismindole-3-carbinoliodine deficiencysulforaphanethyroidthyroid cancervegetables

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Area of Science:

  • Nutritional Science
  • Endocrinology
  • Toxicology

Background:

  • Brassica vegetables contain sulfur compounds like glucosinolates (GLSs) and isothiocyanates (ITCs) with potential health benefits and suspected goitrogenic effects.
  • Previous assumptions suggested Brassica consumption might negatively affect thyroid function, particularly in individuals with existing thyroid conditions.

Approach:

  • A systematic review adhering to PRISMA guidelines was conducted.
  • Analysis included 123 in vitro, animal, and human studies on Brassica's impact on thyroid function markers (TSH, T3, T4, iodine uptake) and thyroid cancer cells.
  • Mechanisms of GLS and ITC goitrogenic potential, study limitations, and future research directions were examined.

Key Points:

  • The majority of evidence contradicts the notion that Brassica plants possess antithyroid effects in humans.
  • GLSs and ITCs, while bioactive, do not appear to impair thyroid function in typical dietary consumption.
  • Adequate iodine intake is crucial and mitigates any potential negative impact from Brassica consumption.

Conclusions:

  • Dietary intake of Brassica vegetables is safe for thyroid health and does not pose a risk to individuals with thyroid dysfunction.
  • Including Brassica vegetables in the daily diet, especially with sufficient iodine, is supported by current scientific evidence.
  • Further research should focus on specific populations and the long-term effects of high Brassica intake with varying iodine levels.