Related Experiment Video
Updated: Jun 28, 2025

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
Published on: November 1, 2019
Ultra-Processed Foods-Dietary Foe or Potential Ally?
Sabrina Nees1, Tymofiy Lutsiv2,3, Henry J Thompson1,2,3
1Graduate Program in Horticulture and Human Health, Colorado State University, Fort Collins, CO 80523, USA.
The link between ultra-processed foods (UPFs) and non-communicable diseases (NCDs) is debated. This review proposes methods to establish causality and guide UPF formulation and selection for consumers.
Area of Science:
- Nutrition Science
- Public Health
- Food Science
Background:
- Non-communicable diseases (NCDs) prevalence is rising in the US.
- Ultra-processed foods (UPFs) consumption is epidemiologically linked to NCDs.
- Causality between UPFs and NCDs remains unproven, with ongoing debate on contributing factors.
Purpose of the Study:
- To propose an investigative process to establish causality between UPFs and NCDs.
- To move beyond current controversies in UPF health outcome research.
- To suggest a paradigm for UPF formulation and consumer selection.
Main Methods:
- Narrative review of existing epidemiological observations and scientific literature.
- Proposal of an investigative framework to identify causal links.
- Development of guidelines for food designers and consumers.
Main Results:
- The current science is inconclusive regarding UPF causality for NCDs.
- Multiple factors are debated: nutrient density, processing, overconsumption, or unknown elements.
- A structured approach is needed to resolve scientific uncertainties.
Conclusions:
- Further research is required to definitively establish the causal relationship between UPFs and NCDs.
- A proposed framework can guide future investigations and industry practices.
- Guidelines for UPF formulation and consumer choice can promote healthier diets.
Related Concept Videos
Obesity
Regulation of Food Intake
Lipids: Dietary Sources and Requirements
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Cause and Effect
Lipid-derived Compounds in the Human Body
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...

