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Multielement Detection of Nonmetals by Barium-Based Post-ICP Chemical Ionization Coupled to Orbitrap-MS
Grace Hahm1, Frenio A Redeker1, Kaveh Jorabchi1
1Department of Chemistry, Georgetown University, Washington, D.C. 20057, United States.
Journal of the American Society for Mass Spectrometry
|April 23, 2024
Summary
This study introduces a novel method for detecting multiple nonmetals using inductively coupled plasma mass spectrometry (ICP-MS). The technique enhances sensitivity and resolves interferences, improving quantitation of elements like fluorine and sulfur.
Area of Science:
- Analytical Chemistry
- Mass Spectrometry
- Elemental Analysis
Background:
- Standard-free quantitation of nonmetals (F, Cl, S, P, Br, I) in ICP-MS is challenged by in-plasma ionization difficulties and isobaric interferences.
- Existing methods for nonmetal detection in ICP-MS require element-specific interference removal, limiting multielement analysis.
- The prevalence of these nonmetals in pharmaceuticals and environmental samples necessitates improved detection techniques.
Purpose of the Study:
- To develop an alternative ICP-MS approach for enhanced multielement nonmetal detection.
- To establish an element-independent method for resolving isobaric interferences in nonmetal analysis.
- To achieve sensitive and accurate quantitation of nonmetals with improved detection limits.
Main Methods:
- Analytes were introduced into an ICP, forming post-plasma species (HF, HCl, H3PO3, H2SO4, HBr, HI).
- These species were chemically ionized using barium-containing ions supplied by nanospray, forming ions like BaF+, BaCl+, etc.
- High-resolution mass spectrometry was used for ion detection, enabling element-independent interference resolution.
Main Results:
- Elemental response factors were linear within two orders of magnitude and independent of analyte chemical structure.
- Detection limits below 1 ng/mL were achieved for Cl, Br, I, and P; 1.8 ng/mL for F and 6.2 ng/mL for S.
- Insights into ionization mechanisms revealed reactivity trends of reagent ions and plasma products, guiding matrix effect management.
Conclusions:
- The developed method offers improved multielement quantitation of nonmetals with enhanced sensitivity and interference removal.
- Understanding ionization mechanisms provides a pathway to further optimize the technique for better performance.
- This approach facilitates more accurate analysis of nonmetals in complex matrices relevant to pharmaceuticals and environmental science.
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