Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Blood Vessels01:07

Development of Blood Vessels

578
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
578
Overview of the Vascular System01:20

Overview of the Vascular System

2.8K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
2.8K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Structure of Blood Vessels01:15

Structure of Blood Vessels

4.4K
Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
4.4K
Blood Flow01:29

Blood Flow

69.6K
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
69.6K
Overview of Blood Vessels01:14

Overview of Blood Vessels

3.2K
The human cardiovascular system comprises five primary types of blood vessels: arteries, arterioles, veins, venules, and capillaries, each serving unique functions.
Arteries and Arterioles: Arteries are muscular and elastic vessels that primarily carry oxygenated blood from the heart to body tissues, except for the pulmonary artery, which carries deoxygenated blood. They have thick walls to withstand high pressure and contain a layer of muscle tissue, allowing them to expand or contract as...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulsatile flow dynamics maintain pulmonary artery architecture.

JCI insight·2026
Same author

Fibrin defines tissue stiffness and biomechanical signaling in regenerating zebrafish hearts as revealed by high-resolution stiffness mapping.

iScience·2026
Same author

Integration of spatial and single-nucleus transcriptomics to map gene expression in the developing mouse kidney.

Development (Cambridge, England)·2025
Same author

Ureteric stromal progenitors give rise to kidney inner cortical pericytes via an arterial mural cell intermediate.

Developmental biology·2025
Same author

Zonal endothelial cell heterogeneity underlies murine renal vascular development.

Angiogenesis·2025
Same author

Pulsatile flow dynamics determine pulmonary arterial architecture.

bioRxiv : the preprint server for biology·2025
Same journal

The Biology of Malaria Parasite Liver Infection.

Cold Spring Harbor perspectives in medicine·2026
Same journal

The Interaction between Diabetes Mellitus and Tuberculosis: Epidemiology, Screening, and Clinical Management.

Cold Spring Harbor perspectives in medicine·2026
Same journal

New Malaria Prevention Modalities: Long-Acting Interventions Beyond Vaccines.

Cold Spring Harbor perspectives in medicine·2026
Same journal

From Parasite to Pill: Harnessing Biology for Breakthroughs in Antimalarial Drug Discovery.

Cold Spring Harbor perspectives in medicine·2026
Same journal

Malaria Parasite Genomics: Decentralization, Diversification, and Development Goals.

Cold Spring Harbor perspectives in medicine·2026
Same journal

Tuberculosis Infection: Diagnosis and Management.

Cold Spring Harbor perspectives in medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2025

Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

11.8K

Vascular Organization: Lessons from Development and Disease.

Steve Spurgin1, Ondine Cleaver2

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Cold Spring Harbor Perspectives in Medicine
|May 1, 2024
PubMed
Summary
This summary is machine-generated.

Vascular growth must coordinate with organ formation. This review explores how blood vessels develop, mature, and maintain quiescence, using pulmonary arteriovenous malformations as a case study.

More Related Videos

Author Spotlight: Studying hiPSC-Derived Endothelial Cells Cultured Under Fluidic-Mediated Mechanical Stimulation
09:12

Author Spotlight: Studying hiPSC-Derived Endothelial Cells Cultured Under Fluidic-Mediated Mechanical Stimulation

Published on: July 28, 2023

1.6K
Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells
09:46

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells

Published on: January 20, 2023

6.1K

Related Experiment Videos

Last Updated: Jun 27, 2025

Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

11.8K
Author Spotlight: Studying hiPSC-Derived Endothelial Cells Cultured Under Fluidic-Mediated Mechanical Stimulation
09:12

Author Spotlight: Studying hiPSC-Derived Endothelial Cells Cultured Under Fluidic-Mediated Mechanical Stimulation

Published on: July 28, 2023

1.6K
Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells
09:46

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells

Published on: January 20, 2023

6.1K

Area of Science:

  • Vascular Biology
  • Organogenesis
  • Physiology

Background:

  • Blood vessels, composed of endothelial cells (ECs) and mural cells, are crucial for organ function.
  • Coordination between vascular development and organ growth is essential but poorly understood.
  • The transition of dynamic endothelium to mature, quiescent vessels and the consequences of disrupted quiescence remain mysterious.

Purpose of the Study:

  • To review fundamental mechanisms of blood vessel formation and maintenance.
  • To emphasize organ-specific vascular development.
  • To examine transient pulmonary arteriovenous malformations as a model for vascular homeostasis.

Main Methods:

  • Review of existing literature on vascular biology and organogenesis.
  • Analysis of intra- and interorgan vascular architecture.
  • Case study of transient pulmonary arteriovenous malformations.

Main Results:

  • Organ formation is tightly linked to coordinated vascular growth.
  • Vascular architecture influences blood flow and angiogenic factor supply, impacting vessel maintenance.
  • Disruption of endothelial quiescence can lead to pathological conditions.

Conclusions:

  • Understanding coordinated vascular and organ development is critical.
  • Mechanisms of endothelial quiescence and its disruption are key areas for future research.
  • Transient pulmonary arteriovenous malformations offer insights into vascular homeostatic processes.