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Electromagnetic drop-on-demand (DoD) technology as an innovative platform for amorphous solid dispersion production.
Abdelrahman M Helmy1, Anqi Lu2, Ishaan Duggal2
1Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Deraya University, Minya, Egypt.
International Journal of Pharmaceutics
|May 4, 2024
Summary
Electromagnetic drop-on-demand (DoD) 3D printing offers a novel solvent evaporation method for creating amorphous solid dispersions (ASDs). This technique enhances drug solubility and bioavailability for poorly soluble medications.
Area of Science:
- Pharmaceutical Technology
- Materials Science
- Drug Delivery Systems
Background:
- Amorphous solid dispersions (ASDs) improve solubility and bioavailability of poorly water-soluble drugs.
- Conventional ASD production relies on melting or solvent evaporation techniques.
- A need exists for advanced manufacturing methods for ASDs.
Purpose of the Study:
- To introduce and evaluate the electromagnetic drop-on-demand (DoD) technique as a novel solvent evaporation method for ASD production.
- To demonstrate the feasibility of producing ASDs using DoD 3D printing for multiple drug-polymer combinations.
Main Methods:
- Investigated three drug-polymer combinations: efavirenz-Eudragit L100-55, lumefantrine-hydroxypropyl methylcellulose acetate succinate, and favipiravir-polyacrylic acid.
- Utilized electromagnetic drop-on-demand (DoD) 3D printing for ASD fabrication.
- Characterized ASDs using polarized light microscopy, DSC, XRPD, and FTIR spectroscopy.
Main Results:
- Confirmed the formation of ASDs for all three drug-polymer combinations via DoD 3D printing.
- Significantly increased the equilibrium solubility of efavirenz (0.03 to 21.18 µg/ml) and lumefantrine (1.26 to 20.21 µg/ml).
- Demonstrated the reliability and effectiveness of the DoD technique for ASD production.
Conclusions:
- Electromagnetic DoD 3D printing is a viable, cutting-edge solvent-evaporation technique for ASD manufacturing.
- This technology holds potential for on-demand and continuous production of ASDs.
- The DoD method offers a promising alternative for enhancing the solubility of poorly soluble drugs.
