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Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

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Updated: Jun 27, 2025

Strategies for Assessing Autistic-Like Behaviors in Mice

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Microglial Dysfunction in Autism Spectrum Disorder.

Jian Meng^1,2, Lingliang Zhang^1,2, Yun-Wu Zhang^1,2

¹Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China.

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry

|May 7, 2024

Summary

This summary is machine-generated.

Microglial dysfunction, neuroinflammation, and gut dysbiosis are linked to autism spectrum disorder (ASD) etiology. This review explores these connections, focusing on altered brain processes and microbiota in ASD.

Keywords:

autism spectrum disorder autophagy gut microbiota microglia neuroinflammation synaptic pruning transcriptome

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Published on: September 6, 2024

Area of Science:

Neuroscience
Immunology
Genetics

Background:

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with unclear molecular origins.
Emerging evidence suggests a role for microglial cells in ASD pathogenesis.
Microglia, the brain's immune cells, are implicated in neuroinflammation and synaptic pruning.

Purpose of the Study:

To review current research on microglial dysfunction in relation to ASD.
To explore the links between neuroinflammation, synaptic pruning, and ASD.
To examine the role of gut microbiota dysbiosis and its correlation with microglial function in ASD.

Main Methods:

Literature review of studies investigating microglial function in ASD.
Analysis of research on neuroinflammation and synaptic pruning in ASD models.
Examination of studies on gut microbiota alterations and their impact on brain health in ASD.

Main Results:

Microglial dysfunction is associated with neuroinflammatory processes in ASD.
Altered transcriptomes and autophagy in microglia are observed in ASD.
Gut microbiota dysbiosis correlates with microglial dysfunction in individuals with ASD.

Conclusions:

Microglial dysfunction represents a significant factor in ASD etiology.
Targeting neuroinflammation and gut microbiota may offer therapeutic avenues for ASD.
Further research is needed to fully elucidate the complex interplay of these factors in ASD.