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Updated: Jun 26, 2025

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells
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Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Published on: April 7, 2016

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Cell Therapies and Gene Therapy for Diabetes: Current Progress

Leila Ghassemifard1,2, Masumeh Hasanlu3, Negin Parsamanesh4,5

  • 1Department of Physiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Current Diabetes Reviews
|May 15, 2024
PubMed

Insights

New diabetes treatments are emerging, including synthetic drugs and advanced gene and cell therapies. Stem cell research shows promise for developing functional beta cells to treat diabetes and its complications.

Area of Science:

  • Biomedical research
  • Therapeutic strategies

Background:

  • Diabetes epidemic requires novel therapeutic strategies.
  • Synthetic medicinal chemistry offers promising drug candidates.
  • Gene and cell therapies are under extensive investigation for diabetes treatment.

Purpose of the Study:

  • To review current cell therapies for diabetes.
  • To discuss vector-based gene therapy for diabetes prevention and treatment.

Main Methods:

  • Review of existing literature on cell and gene therapies for diabetes.
  • Analysis of stem cell differentiation into pancreatic beta cells.
  • Examination of vector-based gene therapy approaches.

Main Results:

  • Gene therapy is an established treatment for various diseases, including diabetes.
  • Stem cells demonstrate potential for in vitro and in vivo functional beta cell development.
  • Cell therapies and gene therapies offer viable strategies for managing diabetes.

Conclusions:

  • Cell and gene therapies represent significant advancements in diabetes treatment.
  • These approaches hold potential for treating diabetes and mitigating complications.
  • Further research into these therapies is crucial for combating the diabetes epidemic.
Keywords:
Diabetescell therapygene therapypancreatic beta cellsstem cellsvector.

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