Cardiovascular Disease and Inpatient Complications in Turner Syndrome: A Propensity Score Analysis

Area of Science:

• Cardiology
• Genetics
• Internal Medicine

Background:

• Turner syndrome is a genetic condition in females characterized by the absence of one X chromosome.
• This condition is associated with various health issues, particularly cardiovascular complications.

Purpose of the Study:

• To investigate the risk of cardiovascular disease in patients with Turner syndrome.
• To evaluate inpatient clinical outcomes for individuals diagnosed with Turner syndrome.

Main Methods:

• Utilized data from the Nationwide Inpatient Sample (NIS) 2016 database.
• Employed propensity score analysis to match patients with and without Turner syndrome.
• Compared cardiovascular disease risks and inpatient outcomes between the two groups.

Main Results:

• Women with Turner syndrome showed significantly higher rates of congenital heart defects, including bicuspid aortic valve and coarctation of the aorta.
• Increased likelihood of aortic aneurysm, ischemic heart disease, heart failure, and atrial fibrillation was observed in Turner syndrome patients.
• Higher incidence of pulmonary arterial hypertension, acute kidney injury, and need for mechanical ventilation were noted in the Turner syndrome cohort.

Conclusions:

• Turner syndrome is linked to a greater prevalence of cardiovascular diseases and inpatient complications.
• Close monitoring and screening for cardiovascular conditions and inpatient complications are recommended for individuals with Turner syndrome.