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Peripapillary Retinoschisis in Glaucoma: A Systematic Review
Maria Carolina Almeida1, Margarida Ribeiro2,3, João Barbosa-Breda2,4,5,6
1Faculty of Medicine, University of Porto.
Journal of Glaucoma
|May 21, 2024
Summary
Peripapillary retinoschisis (PPRS) can affect optical coherence tomography (OCT) glaucoma monitoring. Its precise impact on glaucoma progression remains uncertain, with limited studies showing a clear correlation.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Retinal Imaging
Background:
- Peripapillary retinoschisis (PPRS) detection is increasing with optical coherence tomography (OCT) use.
- PPRS presents challenges in monitoring glaucoma progression.
Approach:
- Systematic review of literature on PPRS in glaucoma patients.
- Searched PubMed, Embase, Web of Science, and Scopus.
- Included 10 studies meeting specific criteria.
Key Points:
- PPRS often overlaps with existing retinal nerve fiber layer defects.
- The association between PPRS and glaucoma progression is inconsistent across studies.
- Only 2 out of 7 studies found a link between PPRS and faster glaucoma progression.
Conclusions:
- PPRS can bias OCT analysis in glaucoma, potentially leading to overestimation of retinal nerve fiber layer thickness.
- Caution is advised to avoid misinterpreting PPRS resolution as rapid disease progression.
- The exact clinical significance of PPRS in glaucoma progression requires further investigation.
