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Trace element status in canine endocrine diseases.
Belén Larrán1, Araceli Loste2, Marta Borobia3
1Departamento de Patoloxía animal, Facultade de Veterinaria, Campus Terra, Universidade de Santiago de Compostela, 27002 Lugo, Spain; Hospital Veterinario Universitario Rof Codina, Facultade de Veterinaria, Campus Terra, Universidade de Santiago de Compostela, 27002 Lugo, Spain.
Trace element levels like arsenic, copper, molybdenum, selenium, and zinc differ in dogs with endocrine diseases. These elements show specific associations with disease markers, offering insights into canine endocrinopathies.
Area of Science:
- Veterinary Medicine
- Analytical Chemistry
- Endocrinology
Background:
- Balanced trace element status is crucial for organism function.
- Trace element concentrations can be altered in various medical conditions, including endocrine diseases.
Purpose of the Study:
- To investigate trace element profiles in dogs with hyperadrenocorticism, diabetes mellitus, and hypothyroidism.
- To explore associations between trace elements and biochemical data using chemometric techniques.
Main Methods:
- Inductively coupled plasma mass spectrometry (ICP-MS) was used to measure thirteen elements in plasma samples.
- Plasma samples were collected from dogs with hyperadrenocorticism (HAC), diabetes mellitus (DM), hypothyroidism (HT), and control dogs.
- Chemometric analysis was employed to identify patterns and associations.
Main Results:
- Significant differences in arsenic (As), copper (Cu), molybdenum (Mo), selenium (Se), and zinc (Zn) were observed.
- Hypothyroid dogs had higher As and lower Se; hyperadrenocorticoid dogs had higher Mo.
- All disease groups showed elevated Cu and Zn compared to controls, with specific increases in DM (Cu) and HAC (Zn).
- Distinct chemometric patterns differentiated disease groups.
- Specific associations were found: Mo-glucose (DM), Cu-fructosamine (DM), As-cortisol (HAC), Se-TT4 (HT), and As-TSH (HT).
Conclusions:
- Trace element profiles are altered in canine endocrinopathies.
- Specific trace elements are associated with distinct endocrine diseases and their biochemical markers.
- Findings provide insights into the complex interplay between trace elements and canine endocrinopathies, suggesting potential for further clinical applications.
