Coronary Angiography in Patients With Left Ventricular Hypertrabeculation/Noncompaction.

Area of Science:

• Cardiology
• Cardiac Imaging
• Genetics

Background:

• Left ventricular hypertrabeculation/noncompaction (LVHT) is a cardiac abnormality with an unclear cause, often linked to neuromuscular conditions.
• The impact of coronary artery disease (CAD) on LVHT prognosis is not well understood.

Purpose of the Study:

• To investigate the role of coronary artery disease (CAD) as a prognostic factor in patients diagnosed with left ventricular hypertrabeculation/noncompaction (LVHT).

Main Methods:

• Retrospective analysis of echocardiographic data from 154 LVHT patients who underwent coronary angiography.
• Assessment of the association between CAD and clinical, echocardiographic, and neurological parameters.
• Evaluation of all-cause death and heart transplantation as primary endpoints.

Main Results:

• Coronary angiography revealed CAD in 53 patients. Patients with CAD were older and had higher rates of angina, diabetes, and hypertension.
• Over a median follow-up of 6.48 years, 39% of patients reached an endpoint (death or heart transplantation).
• No significant difference in mortality or heart transplantation rates was observed between LVHT patients with and without CAD.

Conclusions:

• Coronary artery disease (CAD) does not appear to be a significant predictor of adverse outcomes, such as death or heart transplantation, in individuals with left ventricular hypertrabeculation/noncompaction (LVHT).
• Further research may explore specific management strategies for LVHT patients with co-existing CAD.