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Updated: Jun 24, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Co(III)-Catalyzed Regioselective Functionalization of Isoquinolones with Naphthoquinones
Tamanna Sharma1, Sumit1,2, Sachin1,2
1C-H Activation and Phytochemistry Lab, Chemical Technology Division, CSIR-IHBT, Palampur 176061, India.
Abstract:
A strategy for Co(III)-catalyzed C(sp2)-H alkenylation of N-protected isoquinolones with 1,4-naphthoquinones has been disclosed. The developed protocol was efficiently applied for diversely substituted isoquinolones. Preliminary mechanistic experiments revealed the involvement of a five-membered cobaltacycle as an intermediate. Deuterium labeling experiments suggested the reversible nature of the C-H activation step. The scale-up reaction was also carried out, and the product was utilized as a chemosensor to detect Fe3+ ions.
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