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Hallucinogens and Psychedelics01:27

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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
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Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
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Stutterers' experiences on classic psychedelics: A preliminary self-report study.

Eric S Jackson1, Noam Goldway2, Hope Gerlach-Houck3

  • 1Department of Communicative Sciences and Disorders, New York University, USA.

Journal of Fluency Disorders
|June 4, 2024
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Summary

Classic psychedelics may positively impact stuttering, with many users reporting reduced stuttering and anxiety. However, this preliminary study highlights the need for controlled research due to potential risks.

Keywords:
LSDPsilocybinPsychedelicsQualitativeRedditStuttering

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Stuttering significantly impacts social, occupational, and educational life.
  • Current therapies offer limited efficacy, and no FDA-approved pharmaceutical treatments exist for stuttering.
  • Classic psychedelics show promise for conditions with overlapping symptoms like anxiety and depression.

Purpose of the Study:

  • To explore the potential effects of classic psychedelics on stuttering.
  • To investigate self-reported experiences of individuals who stutter after using psychedelics.

Main Methods:

  • Qualitative analysis of 114 Reddit posts from self-identified stutterers.
  • Inductive extraction of meaningful units and deductive organization into a psychedelic effects framework.
  • Grouping effects into positive, negative, and neutral themes.

Main Results:

  • The majority of users (74.0%) reported positive short-term effects, including reduced stuttering and anxiety.
  • Negative (9.6%), mixed (4.8%), and neutral (11.6%) experiences were also documented.
  • Reported effects encompassed behavioral, emotional, cognitive, belief-based, and social domains.

Conclusions:

  • Preliminary findings suggest psychedelics may influence stuttering.
  • Caution is warranted due to the uncontrolled nature of the study and potential adverse effects.
  • Further research in supervised, clinical settings is suggested to explore this potential.