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Updated: Jun 24, 2025

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

Advances in diagnostic liquid-based cytology.

Hideyuki Abe¹, Akihiko Kawahara¹, Jun Akiba¹

¹Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan.

Cytopathology : Official Journal of the British Society for Clinical Cytology

|June 5, 2024

Summary

Liquid-based cytology (LBC) offers superior reliability and versatility for ancillary testing compared to conventional cytology. This advanced method enhances diagnostic and prognostic capabilities, paving the way for personalized treatments.

Keywords:

ancillary tests cell block cytology diagnostic LBC nucleic acid quality

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Area of Science:

Cytopathology
Molecular Diagnostics
Gynecological Cytology

Background:

Liquid-based cytology (LBC) has significantly advanced gynecological cytology.
Increasing demand for ancillary testing (immunocytochemistry, molecular testing) necessitates improved cytology sample preparation.
Conventional preparation (CP) methods present challenges for comprehensive ancillary testing.

Purpose of the Study:

To review the history and future prospects of LBC in diagnostic cytology.
To discuss the utility of LBC for immunocytochemistry and molecular testing.
To assess the quality of nucleic acids obtained from diagnostic LBC samples.

Main Methods:

Literature review based on internet searches using the keyword 'liquid-based cytology'.
Evaluation of combined diagnostic approaches using LBC and CP.
Assessment of ancillary testing capabilities on LBC supernatant, slides, and cell blocks.

Main Results:

Diagnostic LBC provides high-quality, cell-rich samples suitable for ancillary testing.
LBC demonstrates superior reliability and versatility for ancillary testing compared to CP alone.
Quality of nucleic acids in diagnostic LBC is suitable for molecular analyses.

Conclusions:

Diagnostic LBC is highly effective for ancillary testing, improving cytological diagnosis.
LBC facilitates personalized treatment through enhanced diagnosis and prognosis.
LBC is adaptable to new technologies and poised for future innovations.