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Brain functional specialization and cooperation in Alzheimer's disease
Yue Wu1,2,3, Manman Gao1,2, Lingling Lv1,2
1Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Brain and Behavior
|June 6, 2024
Summary
Alzheimer's disease (AD) patients show altered brain specialization and reduced interhemispheric cooperation. These changes in cerebral function may offer new insights into AD's pathological mechanisms.
Area of Science:
- Neuroscience
- Brain Imaging
- Alzheimer's Disease Research
Background:
- Cerebral specialization and interhemispheric cooperation are crucial for brain function.
- Dysfunction in these areas is linked to Alzheimer's disease (AD) progression, characterized by cognitive decline and asymmetric pathology.
Purpose of the Study:
- To investigate and define hemispheric function properties in AD patients using resting-state functional magnetic resonance imaging (rs-fMRI).
Main Methods:
- Recruited 64 AD patients and 52 healthy controls for MRI and clinical evaluation.
- Calculated brain specialization (autonomy index, AI) and interhemispheric cooperation (connectivity between functionally homotopic voxels, CFH).
Main Results:
- AD patients exhibited increased AI in the left middle occipital gyrus, linked to reduced connectivity in the right temporal lobe.
- Significantly decreased CFH in bilateral precuneus and prefrontal areas was observed in AD patients.
- Machine learning classification based on AI and CFH values showed good diagnostic performance.
Conclusions:
- Individuals with AD display abnormal cerebral specialization and interhemispheric cooperation.
- These findings provide novel insights into the pathological mechanisms underlying Alzheimer's disease.
Keywords:
Alzheimer's diseasecerebral specializationinterhemispheric cooperationresting‐state functional magnetic resonance imagingMore Related Videos
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