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Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
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Muscle Stimulation Frequency01:22

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Wave summation
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Swimming Performance Assessment in Fishes
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β-Alanine Plus Sodium Bicarbonate Co-Supplementation Does Not Decrease Neuromuscular Fatigue in Swimming.

Felipe A Ribeiro1, Danilo R Bertucci2, Carlos A Kalva-Filho3

  • 1Ribeirão Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, BRAZIL.

International Journal of Exercise Science
|June 12, 2024
PubMed
Summary
This summary is machine-generated.

Four weeks of beta-alanine and sodium bicarbonate co-supplementation did not reduce neuromuscular fatigue or improve swimming performance. However, this combined supplementation did increase blood lactate levels in competitive swimmers.

Keywords:
Ergogenic aidsbuffering capacityvoluntary activation

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Area of Science:

  • Sports Science
  • Exercise Physiology
  • Nutritional Supplementation

Background:

  • High-intensity intermittent efforts in swimming can lead to neuromuscular fatigue.
  • Beta-alanine and sodium bicarbonate are supplements investigated for performance enhancement.
  • Co-supplementation strategies aim to maximize ergogenic effects.

Purpose of the Study:

  • To investigate the effects of chronic beta-alanine (βA) plus acute sodium bicarbonate (SB) co-supplementation on neuromuscular fatigue.
  • To assess the impact of this co-supplementation on swimming performance during high-intensity intermittent efforts.
  • To evaluate changes in blood lactate concentrations following the co-supplementation protocol.

Main Methods:

  • Eleven competitive swimmers underwent a 4-week co-supplementation protocol (βA or placebo).
  • Neuromuscular fatigue was assessed using the twitch interpolation technique on the triceps brachii and quadriceps femoris.
  • Performance was measured by mean swimming time, with blood lactate levels monitored.

Main Results:

  • No significant changes in neuromuscular fatigue were observed in the triceps brachii.
  • A significant increase in potentiated twitch delta values was noted in the quadriceps femoris over time, irrespective of the group.
  • Swimming performance did not improve, but blood lactate levels significantly increased in the βA+SB group.

Conclusions:

  • Four-week co-supplementation of βA and SB did not effectively reduce neuromuscular fatigue or enhance swimming performance.
  • The co-supplementation protocol led to a statistically significant increase in blood lactate concentrations.
  • Further research may be needed to explore optimal dosing or different populations for this co-supplementation strategy.