Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

910
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
910
Cardiac Action Potential01:30

Cardiac Action Potential

1.3K
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
1.3K
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

3.2K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
3.2K
Disturbances in Heart Rhythm01:28

Disturbances in Heart Rhythm

933
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
933
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

632
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
632
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Roadmap for Bioelectric Electrochemical Sensing in Cancer.

Bioelectricity·2026
Same author

Chronic Subdural Hematoma Is Not Subdural: Anatomical, Biological, and Therapeutic Implications of a Misleading Definition.

Brain sciences·2026
Same author

HKDC1 contributes to aberrant lysosome-mitochondria contact in Niemann-Pick disease type C.

bioRxiv : the preprint server for biology·2026
Same author

Bitemark analysis using an intraoral 3d scanner (iTero®): experimental study on human skin.

Journal of forensic and legal medicine·2026
Same author

In-Hospital Improved Left Ventricular Ejection Fraction and Prognosis in Acute Heart Failure.

Journal of the American Heart Association·2026
Same author

How to Monitor Transseptal Puncture: A Consensus Statement of the Italian Society of Echocardiography and Cardiovascular Imaging.

Journal of cardiovascular echography·2026
Same journal

Correction to: May Measurement Month 2017: screening for hypertension in Nigeria-Sub-Saharan Africa.

European heart journal supplements : journal of the European Society of Cardiology·2026
Same journal

Optimizing protected PCI strategies in the setting of chronic kidney disease and advanced coronary artery disease: a clinical case-based discussion.

European heart journal supplements : journal of the European Society of Cardiology·2026
Same journal

Patient selection for complex, high-risk indicated percutaneous coronary intervention procedures: an overview.

European heart journal supplements : journal of the European Society of Cardiology·2026
Same journal

Protected percutaneous coronary intervention of complex distal left main disease with Impella CP™ support.

European heart journal supplements : journal of the European Society of Cardiology·2026
Same journal

Impella™-protected PCI in a post-CABG patient with advanced biventricular dysfunction and mitral regurgitation.

European heart journal supplements : journal of the European Society of Cardiology·2026
Same journal

Contemporary evidence in protected percutaneous coronary intervention: a case-based review.

European heart journal supplements : journal of the European Society of Cardiology·2026
See all related articles

Related Experiment Video

Updated: Jun 24, 2025

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

17.3K

Abnormal conduction-induced cardiomyopathy: a poorly explored entity.

Andrea Lalario1,2, Maddalena Rossi1,2, Valentina Allegro1,2

  • 1Centre for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste, Trieste.

European Heart Journal Supplements : Journal of the European Society of Cardiology
|June 13, 2024
PubMed
Summary
This summary is machine-generated.

Abnormal conduction-induced cardiomyopathies result from dyssynchronous biventricular activation, leading to heart dysfunction. Improving this electrical dyssynchrony can restore cardiac function and geometry, particularly without a genetic cause.

Keywords:
Cardiac conduction disordersCardiomyopathiesDyssynchronopathyGenetics

More Related Videos

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
06:40

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System

Published on: May 22, 2018

10.7K
Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
09:16

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

7.7K

Related Experiment Videos

Last Updated: Jun 24, 2025

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

17.3K
Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
06:40

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System

Published on: May 22, 2018

10.7K
Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
09:16

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

7.7K

Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiomyopathy Research

Background:

  • Dyssynchronous biventricular activation, caused by conditions like left bundle branch block or ventricular pacing, impairs global contractility.
  • This abnormal activation leads to systolic dysfunction and left ventricular remodeling, defining a unique group of cardiomyopathies.
  • Existing therapies focus on correcting or mitigating left ventricular (LV) dyssynchrony to reverse cardiac damage.

Purpose of the Study:

  • To review the mechanisms, prevalence, and risk factors of abnormal conduction-induced cardiomyopathies.
  • To outline the diagnostic and therapeutic strategies for these conditions.
  • To highlight the role of multimodal imaging and a multidisciplinary approach in patient management.

Main Methods:

  • Comprehensive literature review of studies on abnormal conduction-induced cardiomyopathies.
  • Analysis of mechanisms linking electrical dyssynchrony to cardiac dysfunction.
  • Evaluation of current diagnostic tools and therapeutic interventions, including device-based therapies and imaging modalities.

Main Results:

  • Eliminating or improving LV dyssynchrony is the primary therapeutic goal, often leading to recovery of cardiac function and geometry.
  • The absence of a genetic background favors a better prognosis and functional recovery.
  • Multimodal imaging and a systematic etiological definition are crucial for guiding therapy.

Conclusions:

  • Abnormal conduction-induced cardiomyopathies are a distinct entity where correcting electrical dyssynchrony is key to treatment.
  • A multidisciplinary, imaging-guided approach is essential for accurate diagnosis and effective, etiology-guided therapy.
  • Further research is needed to address areas of uncertainty and optimize management strategies.