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Does renal failure induce a decrease in cyclosporine blood concentrations?
Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
|January 1, 1985
Summary
This study found that higher creatinine levels in renal transplant patients correlate with lower blood cystine (Cys) levels. Careful monitoring of Cys is essential during uremia to ensure optimal drug levels.
Area of Science:
- Pharmacology
- Nephrology
- Clinical Chemistry
Background:
- Renal transplantation patients often experience altered drug pharmacokinetics due to uremia.
- Cystine (Cys) is a medication requiring careful dosage adjustment in patients with impaired kidney function.
Purpose of the Study:
- To investigate the relationship between blood cystine (Cys) concentrations and renal function in patients post-renal transplantation.
- To determine if uremia affects Cys measurements or its disposition.
Main Methods:
- Blood Cys levels were measured twice weekly using radioimmunoassay (RIA) in nine renal transplant patients.
- Cys dosage was adjusted to maintain blood levels between 100-400 ng/ml.
- In vitro studies assessed the impact of uremic blood on Cys measurement accuracy.
Main Results:
- A significant negative correlation was observed between plasma creatinine and blood Cys concentrations (r = 0.65, p < 0.001).
- This correlation persisted even when oral Cys dosage remained unchanged.
- In vitro tests confirmed that uremic blood did not interfere with Cys measurement.
Conclusions:
- Uremia likely alters the distribution volume and/or gastrointestinal absorption of cystine (Cys).
- Close monitoring of Cys levels is crucial in renal transplant recipients with uremia to manage drug efficacy and safety.