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Related Experiment Video

Updated: Jun 23, 2025

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[Migraine and psychosomatic comorbidity].

Ruth Ruscheweyh1,2, Nadine Lehnen2, Peter Henningsen2

  • 1Neurologische Klinik und Poliklinik, Klinikum der Universität München, München, Germany.

Fortschritte Der Neurologie-Psychiatrie
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Summary

Migraine often co-occurs with other conditions like pain and mental illness, especially in severe cases. Understanding these psychosomatic comorbidities and stress factors is key for effective, multimodal migraine treatment.

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Area of Science:

  • Neurology
  • Psychosomatic Medicine
  • Genetics

Background:

  • Migraine affects 10-15% of the population and frequently co-occurs with other pain, mental, and functional disorders.
  • These psychosomatic comorbidities are more prevalent with increased migraine severity and can negatively impact treatment response.
  • Common etiological factors, including genetics, stress, and a higher incidence in women and those with trauma history, link migraine and its comorbidities.

Purpose of the Study:

  • To propose an extended diathesis-stress model for understanding migraine and its psychosomatic comorbidities.
  • To highlight the importance of considering and treating comorbidities in migraine management.

Main Methods:

  • Literature review and theoretical modeling.
  • Analysis of common etiological and facilitating factors for migraine and comorbidities.
  • Development of an extended diathesis-stress model.

Main Results:

  • Migraine and psychosomatic comorbidities share common risk factors such as genetics, stress, and trauma.
  • An extended diathesis-stress model can explain both isolated migraine and comorbid conditions.
  • Comorbid patients may exhibit poorer responses to standard migraine therapies.

Conclusions:

  • Psychosomatic comorbidities are integral to the migraine experience and should be a focus in clinical practice.
  • Early and multimodal treatment approaches are recommended for patients with migraine and comorbidities.
  • The proposed diathesis-stress model offers a framework for understanding the interplay between vulnerability, stress, and disorder manifestation.