Cognitive Impairment in Multiple Sclerosis: Past, Present, and Future

Sarah A Morrow1

  • 1Department of Clinical Neurosciences, University of Calgary, Hotchkiss Brain Institute, Calgary, Alberta, Canada; Foothills Medical Centre, 907 South Tower, 1403 29th Street NorthWest, Calgary, Alberta T2N 2T9, Canada.

Insights

Cognitive impairment in multiple sclerosis (MS) is common and often overlooked, impacting quality of life. Regular screening for persons with MS (PwMS) using validated tests can improve care and well-being.

Area of Science:

  • Neurology
  • Neuroscience
  • Clinical Medicine

Background:

  • Cognitive impairment is a frequent and often underrecognized issue in multiple sclerosis (MS).
  • Subtle and insidious clinical presentation leads to underestimation of disability in persons with MS (PwMS).

Purpose of the Study:

  • To highlight the underrecognition of cognitive impairment in MS.
  • To emphasize the impact of relapses on cognition.
  • To advocate for regular cognitive screening in PwMS.

Main Methods:

  • Review of recent evidence on cognitive impairment in MS.
  • Analysis of the relationship between MS relapses and cognitive function.

Main Results:

  • MS relapses can affect cognition similarly to physical symptoms and may be the sole manifestation of a relapse.
  • Cognitive impairment is often underdiagnosed in PwMS, leading to an underestimation of overall disability.

Conclusions:

  • Regular screening with validated tests is crucial for improving care for PwMS.
  • Early identification and management of cognitive impairment can enhance the quality of life for individuals with MS.

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