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Hemodialysis-induced positional changes in lamina cribrosa.
Ji Hong Kim1,2, Hyo Chan Jeong1,2, Yong Un Shin1,3
1Department of Ophthalmology, Hanyang University College of Medicine, 222-1, Wangsimni-ro Seongdong-gu, Seoul, 104763, Korea.
Scientific Reports
|July 2, 2024
Summary
Hemodialysis (HD) significantly reduced anterior lamina cribrosa depth (LCD) in patients with end-stage kidney disease (ESKD). This finding suggests hemodialysis impacts the optic nerve head, particularly the lamina cribrosa.
Area of Science:
- Ophthalmology
- Nephrology
- Medical Imaging
Background:
- End-stage kidney disease (ESKD) affects multiple organ systems.
- Optic nerve head (ONH) health is crucial for vision.
- Hemodialysis (HD) is a life-sustaining treatment for ESKD.
Purpose of the Study:
- To investigate the effect of hemodialysis on the lamina cribrosa (LC) of the optic nerve head.
- To assess changes in ONH parameters using swept-source optical coherence tomography (SS-OCT).
- To correlate changes in LC depth with ocular and systemic parameters.
Main Methods:
- Prospective observational study of 29 ESKD patients undergoing HD.
- SS-OCT used to measure ONH parameters: neural canal diameter (NCD), peripapillary vertical height (PVH), and anterior LC depth (LCD).
- Statistical analysis of ONH parameters before and after HD, with correlation analyses.
Main Results:
- A significant decrease in mean anterior LCD from 441.6 ± 139.8 μm to 413.5 ± 141.7 μm post-HD (P=0.001).
- No significant changes observed in NCD and PVH after HD (P=0.841 and P=0.574, respectively).
- Significant correlation found between changes in anterior LCD and mean ocular perfusion pressure (r=0.397, P=0.036).
Conclusions:
- Hemodialysis leads to a significant reduction in anterior lamina cribrosa depth.
- These findings indicate that HD can influence the optic nerve head structure, specifically the LC.
- Further research is warranted to understand the long-term implications of these changes.
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